Evaluation of the role of lipid profile and kidney function in men with type 2 diabetes in the city of Kirkuk
Department of Biology, College of Education for pure Sciences, University of Kirkuk, Kirkuk, Iraq.
Research Article
International Journal of Life Science Research Archive, 2025, 08(02), 023-030.
Article DOI: 10.53771/ijlsra.2025.8.2.0031
Publication history:
Received on 01 March 2025; revised on 07 April 2025; accepted on 10 April 2025
Abstract:
The aim of the current study is to Investigate the of lipid profiles and kidney function markers in the serum of patients with type 2 diabetes and to determine the correlation of these levels with various physiological parameters in patients with T2DM. The experiment was conducted from the beginning of September 2024 to the end of January 2025. Blood samples were collected from patients visiting Kirkuk General Hospital and private laboratories in Kirkuk. The study samples included 90 male participants with an average age of (59.46) years. The study samples were distributed into (60) participants with type 2 diabetes (T2DM) distributed into two groups: one group consisting of (30) T2DM patients with high weights (high body mass index, BMI=32 Kg/m2) and a second group consisting of (30) T2DM patients with normal weights (normal body mass index, BMI=24.18), in addition to (30) participants in the control group (BMI=22.95).
The study results showed a significant increase (p ≤ 0.05) in the concentration of glycated hemoglobin and lipid profile indicators, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), kidney function indicators such as urea and creatinine, and body mass index (BMI) in the affected patients compared to the control group. Additionally, there was a significant decrease (P ≤ 0.05) in the concentration of high-density lipoprotein (HDL) in patients with T2DM compared to the control group. The results also indicated, according to the groups of patients with high and normal weights, a significant increase (P ≤ 0.05) in the concentration of lipid profile indicators, creatinine, and BMI in the group of patients with T2DM with high weights compared to the group of patients with T2DM with normal weights. In addition, there was a significant decrease (P ≤ 0.05) in high-density lipoprotein (HDL) concentration among patients with T2DM who had high weights compared to the group of T2DM patients with normal weights. The results also showed no significant differences (p ≤ 0.05) in the concentration of glycated hemoglobin and urea between the two groups of patients with high weights compared to the group of patients with normal weights.
Keywords:
Lipid profile indicators (TC; TG; HDL; LDL; VLDL); Type 2 diabetes Mellitus (T2DM); BMI; Kidney function indicators (Urea; Creatinine)
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