Acute megakaryoblastic leukemia (AML7) about a case
1 Department of Hematology, Central Laboratory for Medical Biological Analysis, CHU Hassan II, Fez, Morocco.
2 Faculty of Medicine and Pharmacy Sidi Mohammed Benabdallah, Fez, Morocco.
Review
International Journal of Life Science Research Archive, 2024, 06(02), 040–044.
Article DOI: 10.53771/ijlsra.2024.6.2.0050
Publication history:
Received on 31 March 2024; revised on 06 May 2024; accepted on 09 May 2024
Abstract:
Acute myeloid megakaryoblastic leukemia (AML7) is a rare and severe form of acute myeloid leukemia. Its diagnosis is based essentially on cytometric and cytogenetic data, given the complexity of morphological diagnosis. Myelofibrosis and osteolytic lesions may be a particular feature of AML7.
Treatment with chemotherapy is considered, but the outcome is often unfavorable. The gold standard of treatment is bone marrow transplantation.
Our article reports the case of an infant diagnosed with acute megakaryoblastic leukemia initially revealed by a bone marrow failure syndrome and aggravated by a cerebro-orbital extension with osteolytic lesions of the orbital cavity, treated with chemotherapy with a good clinical-biological evolution.
Keywords:
Leukemia; Megakaryoblasts; Medullogram; Myelofibrosis; Immunophenotyping
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