Revolutionizing drug delivery systems: Nanotechnology-based approaches for targeted therapy
1 Enugu State University Teaching Hospital, Parklane, Enugu, Nigeria.
2 Life's Journey Inc. Winnipeg, Manitoba, Canada.
3 Austin Peay State University, Clarksville, TN, USA.
4 Mediclinic Hospital Pietermaritzburg, South Africa.
5 Public Health Specialist, Albada General Hospital, Tabuk, Saudi Arabia.
Review
International Journal of Life Science Research Archive, 2024, 07(01), 040–058.
Article DOI: 10.53771/ijlsra.2024.7.1.0060
Publication history:
Received on 01 July 2024; revised on 06 August 2024; accepted on 08 August 2024
Abstract:
Nanotechnology has emerged as a transformative force in drug delivery systems, offering unprecedented precision in targeting diseased cells while minimizing side effects. This paper explores the revolutionary impact of nanotechnology-based approaches on drug delivery, particularly in the context of targeted therapy for various diseases, including cancer, cardiovascular disorders, and infectious diseases. Nanotechnology enables the design of drug delivery systems at the molecular level, allowing for the development of nanoscale carriers that can deliver therapeutic agents directly to specific cells or tissues. These nanocarriers, such as liposomes, dendrimers, and polymeric nanoparticles, can be engineered to encapsulate drugs and release them in a controlled manner, ensuring that the therapeutic agents reach their intended targets with high efficiency. This targeted approach significantly reduces the off-target effects often associated with conventional drug delivery methods, thereby improving patient outcomes and reducing toxicity. One of the key advantages of nanotechnology in drug delivery is its ability to overcome biological barriers that have traditionally limited the effectiveness of therapies. For example, nanoparticles can be designed to cross the blood-brain barrier, opening new avenues for treating neurological disorders. Similarly, targeted nanoparticles can accumulate in tumor tissues through the enhanced permeability and retention (EPR) effect, allowing for more effective cancer treatment with reduced systemic toxicity. Nanotechnology also facilitates the combination of diagnostic and therapeutic functions, known as theranostics, within a single platform. This dual capability allows for real-time monitoring of drug delivery and therapeutic response, enabling personalized treatment plans that can be adjusted based on the patient’s specific needs. This integration of diagnosis and therapy represents a significant leap forward in the pursuit of precision medicine. Despite the promising potential of nanotechnology-based drug delivery systems, challenges remain, including issues related to scalability, biocompatibility, and regulatory approval. Ongoing research and collaboration between scientists, clinicians, and industry stakeholders are essential to address these challenges and fully realize the benefits of nanotechnology in targeted therapy. In conclusion, nanotechnology-based approaches are revolutionizing drug delivery systems, offering new possibilities for targeted therapy that could significantly improve treatment outcomes and patient quality of life. Continued innovation and collaboration in this field will be crucial in bringing these advanced therapies from the laboratory to clinical practice.
Keywords:
Revolutionizing; Drug Delivery System; Nanotechnology-Based; Approaches; Targeted Therapy
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