GeneXpert contribution in the diagnosis of multi-resistant tuberculosis in new cases at the National University Hospital Centre of Pneumo-Phtisiology of Cotonou (Benin)
1 Faculty of Science and Technology of the University of Abomey-calavi FAST/UAC.
2 Applied Biology Research Laboratory (LARBA), Polytechnic School of Abomey-Calavi (EPAC), University of Abomey-Calavi (UAC), 01 BP 2009, Cotonou, Benin.
Research Article
International Journal of Life Science Research Archive, 2021, 01(02), 038–042.
Article DOI: 10.53771/ijlsra.2021.1.2.0070
Publication history:
Received on 28 September 2021; revised on 08 November 2021; accepted on 10 November 2021
Abstract:
The diagnosis of bacteriologically confirmed pulmonary tuberculosis in Benin and in other developing countries relies on the search for acid-fast bacilli through microscopy despite its limited sensitivity. The objective of this study is to evaluate the contribution of the Xpert test in the diagnosis of multidrug-resistant tuberculosis in all new suspects received at the Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou (CNHU-PPC) of Benin. The biological material consisted of sputum from new suspected TB patients received at CNHU-PPC during the third quarter of 2018. A total of two thousand three hundred and seventy-five (2375) suspected patients were included in the study, of which 52% were men and 48% were women. The most representative age range was 15-24 years, 28%. GeneXpert was able to diagnose pulmonary tuberculosis in 10.02% of patients, including 9.7% rifampicin-susceptible and 0.3% rifampicin-resistant patients who could not be detected by microscopy. This molecular diagnostic tool is of great value for the diagnosis of multidrug-resistant tuberculosis in new suspects.
Keywords:
Tuberculosis; Multidrug-resistant; GeneXpert; Benin
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