Formulation and evaluation of proniosome loaded sertaconazole nitrate for topical application
1 G Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad (Telangana), India.
2 Govt. Polytechnic for Women, Nizamabad.
Research Article
International Journal of Life Science Research Archive, 2021, 01(02), 023–037.
Article DOI: 10.53771/ijlsra.2021.1.2.0060
Publication history:
Received on 08 August 2021; revised on 09 September 2021; accepted on 11 September 2021
Abstract:
Proniosomal technology is a novel solution for poorly soluble drugs. Proniosomes are water-soluble carrier particles which are coated with non-ionic surfactants. Proniosomal gels were prepared by coacervation phase separation method using non-ionic surfactants, lipid carriers and cholesterol as a membrane stabilizer. FTIR compatibility studies revealed that the drug and excipients were compatible. All formulations were evaluated for pH, drug content, extrudability, spreadability, viscosity, in-vitro, ex-vivo, skin irritation and stability studies. Among formulations prepared, F80H1 has shown higher % EE (83.02) and least diffusion through dialysis membrane i.e., 17.68%. With ex-vivo studies, F80H1 formulation has shown highest skin deposition and lower flux of sertaconazole nitrate through the rat skin. F80H1 was selected as final optimized formulation. F80H1 exhibited good stability and SEM studies revealed that the vesicles were spherical in shape. The optimized formulation was found to follow zero order release kinetics and korsmeyer-peppas release mechanism. F80H1 found to be non-irritant and stable from skin irritation and stability studies.
Keywords:
Anti-fungal drugs; Proniosomal gel; Sertaconazole nitrate; Topical delivery
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