The impact of clobetasol and salicylic acid on the response to treatment of local plaque psoriasis within Al- Najaf city
1 Department of Clinical laboratory sciences, College of Pharmacy, University of AlKafeel, Iraq. asia.ali@alkafeel.edu.iq
2 Department of Clinical Pharmacy, \College of Pharmacy, Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, Kufa, Iraq.
3 Department of Clinical laboratory sciences, College of Pharmacy, University of Al-Ameed, Iraq. risamawi@alameed.edu.iq
4 Department of Clinical laboratory sciences, College of Pharmacy, Jabir Bin Hayyan University for Medical and Pharmaceutical Sciences, Iraq.
Research Article
International Journal of Science and Technology Research Archive, 2025, 09(02), 009-032.
Article DOI: 10.53771/ijstra.2025.9.2.0026
Publication history:
Received on 02 August 2025; revised on 11 October 2025; accepted on 16 October 2025
Abstract:
Plaque psoriasis: It is the commonest type of psoriasis, a chronic, immune mediated and genetic based dermatoses, characterizing by redness, thickness and scaly plaques occurring most commonly on the elbows, knees, scalp, and lower back, but any skin surface can be involved, has a major impact on quality of life.
D3 or cholecalciferol: A fat soluble vitamin that has many important and vital roles for normal body physiological activities. Certain types of food in addition to dietary supplements and exposure to sun UVB radiation are sources for this vitamin.
Clobetasol: It is the perfect of topical corticosteroids, works as anti-inflammatory, anti-pruritic and vasoconstrictive properties, and reduces the activity of immune system and is currently used to treat hyperproliferation or inflammatory for plaque psoriasis.
Salicylic acid: It is a keratolytic agent, acted as a scale pulley, helpful to smoothing and eradicate psoriasis scales.
Complete Blood Count (CBC and Erythrocytes Sedimentation Rate (ESR).
Psoriasis Area and Severity Index (PASI): is a widely used appliance in psoriasis tribunals that judges and grades the sternness of psoriatic lesions and the patient’s reaction to treatment.
Aim: To explore the impact of adding urea to salicylic acid and clobetasol combination in improving their antipsoriatic activity in patients with mild to moderate plaque psoriasis, to control signs and symptoms of this disease and to improve the quality of life.
Materials and Method: This study includes 100 samples divided two groups of plaque psoriasis patients whose severity of psoriasis ranges from mild to moderate. A formula containing clobetasol and salicylic acid is given to the first group of plaque psoriasis patients (Control), and a formula containing clobetasol and salicylic acid in addition to Vitamin D3 is given to the second group of patient’s plaque psoriasis (case). The levels of lymphocytes, erythrocytes sedimentation rate (ESR) was measured, and the Score was calculated for both groups and compared with the time and drug response rate for both groups.
Results: The study included 100 psoriatic patients divided to 63 were female and 37 were male. The ages of the patients ranged from 20-65 years. The WBC, lymphocytes, ESR and PASI mark were resolute before the treatment for control and case groups to be non-significant (P> 0.03, 0.09, 0.52 and 0.32). WBC and Lymphocytes, ESR and PASI score values were lower after adding vitamin D3 to the regimen of salicylic acid and clobetasol than without adding D3 to be significant (P> 0.00, 0.01, 0.02 and 0.00).
Conclusion: It was found that concomitant management with vitamin D3 enhances the effectiveness of topical treatment (salicylic acid & clobetasol) as anti-psoriatic effect and reduces the time required for treatment. The signs and indicators of plaque psoriasis were controlled and the quality of life improved
Keywords:
Psoriasis; Clobetasol; Salicylic acid; Corticosteroids; Immune system; Gender
Full text article in PDF:
Copyright information:
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0