Developing transdermal patch from Momordica charantia L. fruit using polyvinyl alcohol and ethyl cellulose potentially as anti-inflammatory dosage form
1 Department of Pharmacy, Faculty of Pharmacy, National Institute of Science and Technology, Moch. Kahfi II St., Bhumi Srengseng Indah No.13, Jagakarsa, South Jakarta, Indonesia 12630.
2 Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, Universitas Pancasila, Srengseng Sawah, Jagakarsa, South Jakarta, Indonesia 12640.
Research Article
International Journal of Science and Technology Research Archive, 2022, 03(02), 245-252.
Article DOI: 10.53771/ijstra.2022.3.2.0160
Publication history:
Received on 02 November 2022; revised on 20 December 2022; accepted on 22 December 2022
Abstract:
Introduction: Anti-inflammatory medication is currently sufficiently developed for the ease of application and effectiveness of therapy. Development of natural ingredients that are applied through the skin is needed to get a profitable product. This study aimed to develop bitter melon (Momordica charantia L.) fruit as an anti-inflammatory agent using transdermal patch preparations.
Materials and Methods: Dried bitter melon powder was macerated using 96% ethanol, followed by evaporation until a viscous extract was obtained. Bitter melon fruit extract (BMFE) 30% was prepared into three patch transdermal preparations using combinations of polyvinyl alcohol (PVA) and ethyl cellulose (EC) as bases. A mixture of BMFE, propylene glycol, and glycerin was added to the bases and mixed until homogeneous. The entire mass was poured into a mold, coated with aluminum foil, allowed to stand for 24 h, and dried in an oven at 40 °C for 30 min. All preparations of the transdermal patch were evaluated for their physical and chemical characteristics as well as their anti-inflammatory effects
Results: All transdermal patch preparations had solid form, visible brown, weight 0.424 -0.432 g, thickness 0.344 – 0.320 mm, folding endurance of more than 300, pH 4.84 – 4.87, and hygroscopicity 6.50 - 6.99 %. All preparations showed a decrease in the diameter of the edema, but this was not significant; after the 90th minute, the edema diameter was significantly reduced.
Conclusion: This study showed that BMFE can be used for anti-inflammatory patch preparation and has the potential to be developed as a transdermal anti-inflammatory dosage form.
Keywords:
Anti-inflammation; Bitter melon; Characterization; Transdermal patch
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