Serum transformation growth factor β1 levels in nephropathy diabetic patients attending specialist hospital and Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria
1 Department of Chemical Pathology School of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
2 Department of Biochemistry and Molecular Biology, Faculty of Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
3 Department of Internal Medicine, Faculty of Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University Sokoto, Nigeria.
4 Department of Haematology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Research Article
International Journal of Science and Technology Research Archive, 2022, 03(02), 009–019.
Article DOI: 10.53771/ijstra.2022.3.2.0042
Publication history:
Received on 17 June 2022; revised on 26 September 2022; accepted on 29 September 2022
Abstract:
Introduction: Diabetic nephropathy is among the major causes of mortality and morbidity in type 1 & type 2 diabetes and is strongly associated with cardiovascular disease outcomes. Higher blood pressure and poor glycaemic control were reported to be the most common risk factors influencing the progress of diabetic nephropathy. This study was designed to determine the diagnostic and prognostic potential of the serum transformation growth factor β1 [TGF β1] in normoalbuminuric, microalbuminuric, macroalbuminuric and end-stage renal disease type 2 diabetic nephropathy patients.
Materials and Methods: The transformation growth factor β1 was measured using ELISA test kits and serum creatinine was assessed by the modified Jaffe method while estimated glomerular filtration rate [EGFR] in the study was evaluated by the MDRD equation (adjusted for four variables).
Results: The levels of serum transformation growth factor β1 and urine albumin/creatinine ratio were significantly increased (p < 0.05) across the diabetes nephropathy stages, while the estimated glomerular filtration rate was progressively decreased (p < 0.05). Serum creatinine was significantly increased (p < 0.05) with the progression of diabetic nephropathy.
Conclusion: Transformation growth factor β1 might have the potentials to be used as a diagnostic and prognostic marker for diabetic nephropathy.
Keywords:
Diabetic nephropathy; Transformation growth factor β1; DN stage; Nigeria
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